Conference
Abstract ED03-04: Using epigenetic biomarkers as prognostic and predictive markers in non-small cell lung cancer (NSCLC) and the promise of epigenetic therapy
Abstract
Abstract
Epigenetic gene silencing mediated through aberrant DNA methylation and histone deacetylation is a key contributor to lung carcinogenesis. We have defined the utility of a panel of promoter region DNA methylation markers as a robust potential molecular system for re-staging stage 1 non small cell lung cancer (NSCLC) to molecular stage 3 disease. The significance of our finding is that silencing of these gene markers …
Authors
Brock MV; Juergens RA; Wrangle J; Vendetti FP; Murphy S; Zhao M; Coleman B; Sebree R; Rodgers K; Hooker CM
Volume
20
Publisher
American Association for Cancer Research (AACR)
Publication Date
September 1, 2011
DOI
10.1158/1055-9965.disp-11-ed03-04
Conference proceedings
Cancer Epidemiology Biomarkers & Prevention
Issue
10_Supplement
ISSN
1055-9965