Journal article
Spironolactone Metabolism: Steady‐State Serum Levels of the Sulfur‐Containing Metabolites
Abstract
Metabolism of spironolactone in man is extensive and complex. For many years the dethioacetylated metabolite, canrenone, was assumed to be the major metabolite. However, recent studies using specific high performance liquid chromatography (HPLC) have demonstrated the presence of spironolactone and the sulfur-containing metabolites 7 alpha-thiomethylspirolactone (IV) and 6 beta-hydroxy-7 alpha-thiomethylspirolactone (V), in addition to …
Authors
Gardiner P; Schrode K; Quinlan D; Martin BK; Boreham DR; Rogers MS; Stubbs K; Smith M; Karim A
Journal
The Journal of Clinical Pharmacology, Vol. 29, No. 4, pp. 342–347
Publisher
Wiley
Publication Date
April 1989
DOI
10.1002/j.1552-4604.1989.tb03339.x
ISSN
0091-2700