Journal article
Cisplatin-modification of DNA repair and ionizing radiation lethality in yeast, Saccharomyces cerevisiae
Abstract
Cis-diamminedichloroplatinum II (cisplatin) is a DNA inter- and intrastrand crosslinking agent which can sensitize prokaryotic and eukaryotic cells to killing by ionizing radiation. The mechanism of radiosensitization is unknown but may involve cisplatin inhibition of repair of DNA damage caused by radiation. Repair proficient wild type and repair deficient (rad52, recombinational repair or rad3, excision repair) strains of the yeast …
Authors
Dolling J-A; Boreham DR; Brown DL; Raaphorst GP; Mitchel REJ
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 433, No. 2, pp. 127–136
Publisher
Elsevier
Publication Date
March 1999
DOI
10.1016/s0921-8777(98)00069-x
ISSN
0027-5107