Journal article
The Influence of TRP53 in the Dose Response of Radiation-Induced Apoptosis, DNA Repair and Genomic Stability in Murine Haematopoietic Cells
Abstract
Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA …
Authors
Lemon JA; Taylor K; Verdecchia K; Phan N; Boreham DR
Journal
Dose-Response, Vol. 12, No. 3,
Publisher
SAGE Publications
Publication Date
July 1, 2014
DOI
10.2203/dose-response.14-008.lemon
ISSN
1540-1421