Journal article
A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives
Abstract
A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image bone metabolism and bacterial infection using both active and pretargeting strategies was demonstrated. The 99mTc-labelled HYNIC-tetrazine was synthesized in 75% yield and exhibited high stability in vitro and in vivo. A trans-cyclooctene (TCO)-labelled bisphosphonate (TCO-BP) that binds …
Authors
Vito A; Alarabi H; Czorny S; Beiraghi O; Kent J; Janzen N; Genady AR; Alkarmi SA; Rathmann S; Naperstkow Z
Journal
PLOS ONE, Vol. 11, No. 12,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0167425
ISSN
1932-6203