Journal article
Menin Is a Regulator of the Stress Response in Drosophila melanogaster
Abstract
Menin, the product of the multiple endocrine neoplasia type I gene, has been implicated in several biological processes, including the control of gene expression and apoptosis, the modulation of mitogen-activated protein kinase pathways, and DNA damage sensing or repair. In this study, we have investigated the function of menin in the model organism Drosophila melanogaster. We show that Drosophila lines overexpressing menin or an RNA …
Authors
Papaconstantinou M; Wu Y; Pretorius HN; Singh N; Gianfelice G; Tanguay RM; Campos AR; Bédard P-A
Journal
Molecular and Cellular Biology, Vol. 25, No. 22, pp. 9960–9972
Publisher
Taylor & Francis
Publication Date
November 1, 2005
DOI
10.1128/mcb.25.22.9960-9972.2005
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acridine OrangeAnimalsApoptosisBlotting, WesternCell ProliferationChromatin ImmunoprecipitationDNADNA DamageDNA RepairDown-RegulationDrosophila ProteinsDrosophila melanogasterFluorescent DyesGene Expression Regulation, DevelopmentalGenotypeHSP70 Heat-Shock ProteinsHeat-Shock ProteinsHot TemperatureHypoxiaImmunohistochemistryMitosisMutationOxidative StressProto-Oncogene ProteinsRNA InterferenceTemperatureTime FactorsTracheaTransgenesbeta-Galactosidase