Journal article
Sleep of transgenic mice producing excess rat growth hormone
Abstract
The effects of chronic excess of growth hormone (GH) on sleep-wake activity was determined in giant transgenic mice in which the metallothionein-1 promoter stimulates the expression of rat GH (MT-rGH mice) and in their normal littermates. In the MT-rGH mice, the time spent in spontaneous non-rapid eye movement sleep (NREMS) was enhanced moderately, and rapid eye movement sleep (REMS) time increased greatly during the light period. After a 12-h …
Authors
Hajdu I; Obal F; Fang J; Krueger JM; Rollo CD
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 282, No. 1, pp. r70–r76
Publisher
American Physiological Society
Publication Date
January 1, 2002
DOI
10.1152/ajpregu.00485.2001
ISSN
0363-6119