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Genome-wide analyses identify SCN5A as a...
Journal article

Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency

Abstract

Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a …

Authors

Thériault S; Imboden M; Biggs ML; Austin TR; Aeschbacher S; Schaffner E; Brody JA; Bartz TM; Risch M; Grossmann K

Journal

iScience, Vol. 25, No. 10,

Publisher

Elsevier

Publication Date

October 2022

DOI

10.1016/j.isci.2022.105210

ISSN

2589-0042