Journal article
[18F]Fluoro-l-dopa for the in vivo study of intracerebral dopamine
Abstract
6-[18F]Fluoro-L-dopa was designed to trace the dopamine metabolism in the brain with positron tomography. 6-[18F]Fluoro-L-dopa resembles natural L-dopa biochemically, it crosses the blood-brain barrier with the similar kinetics, it is decarboxylated by dopa decarboxylase and is stored intraneuronally in vesicles. In addition the rate of O-methylation of 6-[18F]fluoro-L-dopa by catechol-O-methyl transferase is only 1/4 of that of natural L-dopa. …
Authors
Firnau G; Garnett ES; Chirakal R; Sood S; Nahmias C; Schrobilgen G
Journal
Applied Radiation and Isotopes, Vol. 37, No. 8, pp. 669–675
Publisher
Elsevier
Publication Date
January 1986
DOI
10.1016/0883-2889(86)90260-1
ISSN
0969-8043