Anomalous sedimentation of high molecular weight...

Anomalous sedimentation of high molecular weight denatured mammalian DNA

Abstract

High molecular weight mammalian DNA (of greater than 5 × 108 daltons) appears to sediment anomalously in alkaline sucrose density gradients if centrifugation is at high speed. More accurate sedimentation profiles of this DNA may be obtained following low speed centrifugation.

Authors

McBurney MW; Graham FL; Whitmore GF

Journal

Biochemical and Biophysical Research Communications, Vol. 44, No. 1, pp. 171–177

Publisher

Elsevier

Publication Date

July 2, 1971

DOI

10.1016/s0006-291x(71)80174-2

ISSN

0006-291X

Associated Experts

Frank Lawson Graham

Professor Emeritus, Faculty of Science

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