Journal article
Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene
Abstract
Virus specific, major histocompatibility complex-restricted, cytotoxic T lymphocytes (CTL) generated in Fischer strain rats infected with human adenovirus type 5 (Ad5) were found to recognize antigenic determinants encoded within the Ad5 early region 1A (E1A) gene. Preliminary mapping studies suggest that the E1A CTL epitopes are encoded within the regions between bp 625 to 810 and 916 to 974 in the first exon of this gene. These epitope-coding …
Authors
Routes JM; Bellgrau D; McGrory WJ; Bautista DS; Graham FL; Cook JL
Journal
Journal of Virology, Vol. 65, No. 3, pp. 1450–1457
Publisher
American Society for Microbiology
Publication Date
March 1991
DOI
10.1128/jvi.65.3.1450-1457.1991
ISSN
0022-538X