Journal article
Mucosal Immunity and Protection after Intranasal Immunization with Recombinant Adenovirus Expressing Herpes Simplex Virus Glycoprotein B
Abstract
A recombinant adenovirus (Ad) expressing glycoprotein B (gB) of herpes simplex virus (HSV) type 1 (AdgB8) was evaluated as a mucosal vaccine candidate. When administered intranasally (inl) to C57B1/6 mice, AdgB8 induced levels of serum anti-HSV gB IgG antibodies similar to those of mice immunized intraperitoneally (ip), which neutralized both HSV-1 and -2. Mice immunized inl with AdgB8 produced secretory IgA specific for HSV gB, but mice …
Authors
Gallichan WS; Johnson DC; Graham FL; Rosenthal KL
Journal
Journal of Infectious Diseases, Vol. 168, No. 3, pp. 622–629
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 1993
DOI
10.1093/infdis/168.3.622
ISSN
0022-1899
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Administration, IntranasalAnimalsAntibodies, ViralCross ReactionsFemaleHerpes SimplexImmunoglobulin AImmunoglobulin GMiceMice, Inbred C57BLNasal MucosaNasal SeptumNeutralization TestsRecombinant ProteinsSpleenSurvival AnalysisT-Lymphocytes, CytotoxicVaccinationVaccines, SyntheticViral Envelope Proteins