Journal article
Herpes Simplex Virus (HSV) Glycoproteins B and K Inhibit Cell Fusion Induced by HSV Syncytial Mutants
Abstract
Herpes simplex virus type 1 (HSV-1) glycoproteins K and B (gK and gB) are intimately involved in virus-induced fusion of cells. Certain mutations in the UL27 (gB) and UL53 (gK) genes confer a syncytial (syn) phenotype characterized by extensive fusion of infected cells and giving rise to multinucleated cells. We have used HSV-1 syn mutants in conjunction with transfected cells or adenovirus vectors to overexpress wild-type gK or gB, in order to …
Authors
Hutchinson L; Graham FL; Cai W; Debroy C; Person S; Johnson DC
Journal
Virology, Vol. 196, No. 2, pp. 514–531
Publisher
Elsevier
Publication Date
October 1993
DOI
10.1006/viro.1993.1507
ISSN
0042-6822