Conference
Abstract B207: Nivolumab +/- Ipilimumab in patients with hypermutated cancers detected in blood: NIMBLE
Abstract
Abstract
Background: During DNA replication, there is an increased risk for base substitution due to replicative errors caused by DNA polymerases, which have error rates of approximately 10-5 per base pair per cell division. One of the mechanisms to counteract these errors involves real-time proofreading via exonuclease activity present in both DNA polymerase ε, which synthesizes the leading strand and is encoded by POLE, and …
Authors
Rizvi N; Tang P; Bhardwaj N; Chan TA; Weber JS; Vickers M; Pintova S; Hirte H; Segal NH; Dhani N
Volume
7
Pagination
pp. b207-b207
Publisher
American Association for Cancer Research (AACR)
Publication Date
February 1, 2019
DOI
10.1158/2326-6074.cricimteatiaacr18-b207
Conference proceedings
Cancer Immunology Research
Issue
2_Supplement
ISSN
2326-6066