Amyloid‐independent vascular contributions to cortical atrophy and cognition in a multi‐center mixed cohort with low to severe small vessel disease

Abstract Background Small vessel disease (SVD) often co‐exists with Alzheimer’s disease (AD) pathology (up to 60%) and may facilitate AD progression. However, SVD is currently not integrated as a pathological factor within the ATN research criteria. Up to now, the majority of studies that investigated effects of SVD on brain atrophy and cognition were limited to either AD cohorts with low SVD burden (e.g., ADNI) or cognitively normal elderly …