Journal article
Dextran Mass Ratio Controls Particle Drying Dynamics in a Thermally Stable Dry Powder Vaccine for Pulmonary Delivery
Abstract
Abstract
PurposeThermally stable, spray dried vaccines targeting respiratory diseases are promising candidates for pulmonary delivery, requiring careful excipient formulation to effectively encapsulate and protect labile biologics. This study investigates the impact of dextran mass ratio and molecular weight on activity retention, thermal stability and aerosol behaviour of a labile adenoviral vector (AdHu5) encapsulated within a spray dried …
Authors
Manser M; Morgan BA; Feng X; Rhem RG; Dolovich MB; Xing Z; Cranston ED; Thompson MR
Journal
Pharmaceutical Research, Vol. 39, No. 9, pp. 2315–2328
Publisher
Springer Nature
Publication Date
9 2022
DOI
10.1007/s11095-022-03341-8
ISSN
0724-8741