Mapping of a 14,000-dalton antigen to early region 4 of the human adenovirus 5 genome

An early 14,000-dalton (14K) antigen of adenovirus 5, hitherto designated 10.5K and thought to be from early region 1 (E1), has been shown to be a product of region E4 on the following evidence. In KB cells infected with the adenovirus 5 mutants dl312 and dl313, containing large deletions in region E1, this antigen was produced in a form having the same mobility as that in wild-type infections. In a range of rodent cells transformed by …