Journal article
Cell Permeating Nano-Complexes of Amphiphilic Polyelectrolytes Enhance Solubility, Stability, and Anti-Cancer Efficacy of Curcumin
Abstract
Many hydrophobic drugs encounter severe bioavailability issues owing to their low aqueous solubility and limited cellular uptake. We have designed a series of amphiphilic polyaspartamide polyelectrolytes (PEs) that solubilize such hydrophobic drugs in aqueous medium and enhance their cellular uptake. These PEs were synthesized through controlled (∼20 mol %) derivatization of polysuccinimide (PSI) precursor polymer with hydrophobic amines (of …
Authors
Fatima MT; Chanchal A; Yavvari PS; Bhagat SD; Gujrati M; Mishra RK; Srivastava A
Journal
Biomacromolecules, Vol. 17, No. 7, pp. 2375–2383
Publisher
American Chemical Society (ACS)
Publication Date
July 11, 2016
DOI
10.1021/acs.biomac.6b00417
ISSN
1525-7797