Journal article
Synthesis, Radiolabeling, and In Vivo Imaging of PEGylated High-Generation Polyester Dendrimers
Abstract
A fifth generation aliphatic polyester dendrimer was functionalized with vinyl groups at the periphery and a dipicolylamine Tc(I) chelate at the core. This structure was PEGylated with three different molecular weight mPEGs (mPEG160, mPEG350, and mPEG750) using thiol-ene click chemistry. The size of the resulting macromolecules was evaluated using dynamic light scattering, and it was found that the dendrimer functionalized with mPEG750 was …
Authors
McNelles SA; Knight SD; Janzen N; Valliant JF; Adronov A
Journal
Biomacromolecules, Vol. 16, No. 9, pp. 3033–3041
Publisher
American Chemical Society (ACS)
Publication Date
September 14, 2015
DOI
10.1021/acs.biomac.5b00911
ISSN
1525-7797