Journal article
Pretargeted PET of Osteodestructive Lesions in Dogs
Abstract
The last decade has witnessed the creation of a highly effective approach to in vivo pretargeting based on the inverse electron demand Diels-Alder (IEDDA) click ligation between tetrazine (Tz) and trans-cyclooctene (TCO). Despite the steady progression of this technology toward the clinic, concerns have persisted regarding whether this in vivo chemistry will work in humans given their larger size and blood volume. In this work, we describe the …
Authors
Maitz CA; Delaney S; Cook BE; Genady AR; Hoerres R; Kuchuk M; Makris G; Valliant JF; Sadeghi S; Lewis JS
Journal
Molecular Pharmaceutics, Vol. 19, No. 9, pp. 3153–3162
Publisher
American Chemical Society (ACS)
Publication Date
September 5, 2022
DOI
10.1021/acs.molpharmaceut.2c00220
ISSN
1543-8384