Journal article
PS2 - 171 Bmi1 Identifies Treatment-Refractory Stem Cells in Human Glioblastoma
Abstract
Glioblastoma (GBM) is an aggressive brain tumor that is resistant to conventional radiation and cytotoxic chemotherapies. We hypothesize that brain tumor initiating cells (BTICs), a subpopulation of treatment-resistant cells with stem cell properties cause tumor relapse and a subset of neural stem cell genes regulate BTIC self-renewal, driving GBM recurrence. We adapted the existing treatment protocol for adults with primary GBM for in vivo …
Authors
Vora P; Qazi M; Venugopal C; Subapanditha M; Mahendram S; Chokshi C; Singh M; Bakhshinyan D; McFarlane N; Singh S
Journal
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 43, No. S4, pp. s13–s13
Publisher
Cambridge University Press (CUP)
Publication Date
10 2016
DOI
10.1017/cjn.2016.366
ISSN
0317-1671