Journal article
TMOD-23. DYNAMIC PATTERNS OF GLIOBLASTOMA CLONAL EVOLUTION IN RESPONSE TO CHEMORADIOTHERAPY
Abstract
Despite aggressive multimodal therapy, glioblastoma (GBM) remains incurable and inevitably relapses. Recent data have implicated intratumoral heterogeneity as the driver of therapy resistance and tumour relapse in GBM. Models that capture the evolution of GBM biology in response to standard-of-care (SoC) chemoradiotherapy will allow for the identification of cellular mechanisms that govern GBM therapy failure. In this study, we coupled cellular …
Authors
Qazi M; Venugopal C; Vora P; Nixon A; Desmond K; Singh M; Neil S; Subapanditha M; Tong A; Bakhshinyan D
Journal
Neuro-Oncology, Vol. 20, No. suppl_6, pp. vi273–vi273
Publisher
Oxford University Press (OUP)
Publication Date
November 5, 2018
DOI
10.1093/neuonc/noy148.1135
ISSN
1522-8517