Biophysical compartment models for single-shell diffusion MRI in the human brain: a model fitting comparison

Clinically oriented studies commonly acquire diffusion MRI (dMRI) data with a single non-zerob-value (i.e. single-shell) and diffusion weighting ofb= 1000 s mm^-2. To produce microstructural parameter maps, the tensor model is usually used, despite known limitations. Although compartment models have demonstrated improved fits in multi-shell dMRI data, they are rarely used for single-shell parameter maps, where their effectiveness is unclear from …