Journal article
The risks of breast and ovarian cancer associated with the Ashkenazi Jewish founder allele BRCA2 6174delT
Abstract
Approximately 1% of the Ashkenazi Jewish population carries the BRCA2 6174delT (c.5946del) pathogenic variant. It is important to have accurate knowledge of the risks of breast and ovarian cancer associated with this specific variant so that women may be counseled accordingly. In this prospective study, we estimated the risks of breast and ovarian cancer associated with the 6174delT variant compared with the risks for other pathogenic variants …
Authors
Finch A; Metcalfe K; Akbari M; Friedman E; Tung N; Rosen B; Eisen A; Karlan B; Foulkes W; Neuhausen SL
Journal
Clinical Genetics, Vol. 101, No. 3, pp. 317–323
Publisher
Wiley
Publication Date
March 2022
DOI
10.1111/cge.14098
ISSN
0009-9163