Journal article
Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries
Abstract
RATIONALE: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports of D-TGA patients with rare variants in individual genes, the majority of D-TGA cases remain genetically elusive. Familial recurrence patterns and the observation that most cases with D-TGA are sporadic suggest a polygenic inheritance for the disorder, yet this …
Authors
Škorić-Milosavljević D; Tadros R; Bosada FM; Tessadori F; van Weerd JH; Woudstra OI; Tjong FVY; Lahrouchi N; Bajolle F; Cordell HJ
Journal
Circulation Research, Vol. 130, No. 2, pp. 166–180
Publisher
Wolters Kluwer
Publication Date
January 21, 2022
DOI
10.1161/circresaha.120.317107
ISSN
0009-7330