Journal article
The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation
Abstract
BACKGROUND & AIMS: Circadian rhythms are daily physiological oscillations driven by the circadian clock: a 24-hour transcriptional timekeeper that regulates hormones, inflammation, and metabolism. Circadian rhythms are known to be important for health, but whether their loss contributes to colorectal cancer is not known. We tested the nonredundant clock gene Bmal1 in intestinal homeostasis and tumorigenesis, using the Apcmin model of colorectal …
Authors
Stokes K; Nunes M; Trombley C; Flôres DEFL; Wu G; Taleb Z; Alkhateeb A; Banskota S; Harris C; Love OP
Journal
Cellular and Molecular Gastroenterology and Hepatology, Vol. 12, No. 5, pp. 1847–1872.e0
Publisher
Elsevier
Publication Date
2021
DOI
10.1016/j.jcmgh.2021.08.001
ISSN
2352-345X