Journal article
In vitro evaluation of CAR-T cells in patient-derived glioblastoma models
Abstract
Advances in chimeric antigen receptor (CAR) T cell therapies have led to the modality dominating translational cancer research; however, a standardized protocol for evaluating such therapies in vitro is needed. This protocol details the in vitro preclinical evaluation of CAR-T cell therapies for glioblastoma (GBM), including target cell cytotoxicity and T cell proliferation, activation, and cytokine release assays. For complete details on the …
Authors
Brakel BA; Chokshi CR; Salim SK; Venugopal C; Singh S
Journal
STAR Protocols, Vol. 2, No. 4,
Publisher
Elsevier
Publication Date
December 2021
DOI
10.1016/j.xpro.2021.100920
ISSN
2666-1667