Journal article
Secondary Analysis of a Systematic Review: Are Antifungal Noninferiority Trials at Risk of Eroding Effectiveness Because of Biocreep?
Abstract
Noninferiority randomized controlled trial (RCT) effectiveness may erode when results favor the active control over time and when a decreasingly effective control arm is used in serial trials. We analyzed 32 antifungal noninferiority RCTs (NI-RCTs) for these scenarios in this secondary analysis of a systematic review. Our exploratory analysis suggests that the erosion risk in the effectiveness of antifungal noninferiority trials is uncommon. …
Authors
Komorowski AS; Bai AD; Cvetkovic A; Mourad O; Lo CKL; Li XX; Mokashi V; Findlater A; Duncan DB; Fuller C
Journal
Antimicrobial Agents and Chemotherapy, Vol. 66, No. 1, pp. e01627–e01621
Publisher
American Society for Microbiology
Publication Date
January 18, 2022
DOI
10.1128/aac.01627-21
ISSN
0066-4804