Journal article
Epigenetic Age and the Risk of Incident Atrial Fibrillation
Abstract
BACKGROUND: The most prominent risk factor for atrial fibrillation (AF) is chronological age; however, underlying mechanisms are unexplained. Algorithms using epigenetic modifications to the human genome effectively predict chronological age. Chronological and epigenetic predicted ages may diverge in a phenomenon referred to as epigenetic age acceleration (EAA), which may reflect accelerated biological aging. We sought to evaluate for …
Authors
Roberts JD; Vittinghoff E; Lu AT; Alonso A; Wang B; Sitlani CM; Mohammadi-Shemirani P; Fornage M; Kornej J; Brody JA
Journal
Circulation, Vol. 144, No. 24, pp. 1899–1911
Publisher
Wolters Kluwer
Publication Date
December 14, 2021
DOI
10.1161/circulationaha.121.056456
ISSN
0009-7322