Journal article
PLG Scaffold Delivered Antigen-Specific Regulatory T Cells Induce Systemic Tolerance in Autoimmune Diabetes
Abstract
Islet transplantation is a promising treatment for human type 1 diabetes mellitus. Transplantation requires systemic immunosuppression, which has numerous deleterious side effects. Islet antigen-specific regulatory T cells (Tregs) have been shown to protect islet grafts from autoimmune destruction in the nonobese diabetic (NOD) model when co-localized in the kidney capsule. An extra-hepatic transplant site was established by transplanting …
Authors
Graham JG; Zhang X; Goodman A; Pothoven K; Houlihan J; Wang S; Gower RM; Luo X; Shea LD
Journal
Tissue Engineering Part A, Vol. 19, No. 11-12, pp. 1465–1475
Publisher
Mary Ann Liebert
Publication Date
6 2013
DOI
10.1089/ten.tea.2012.0643
ISSN
1937-3341