Journal article
Transient B-Cell Depletion Combined With Apoptotic Donor Splenocytes Induces Xeno-Specific T- and B-Cell Tolerance to Islet Xenografts
Abstract
Peritransplant infusion of apoptotic donor splenocytes cross-linked with ethylene carbodiimide (ECDI-SPs) has been demonstrated to effectively induce allogeneic donor-specific tolerance. The objective of the current study is to determine the effectiveness and additional requirements for tolerance induction for xenogeneic islet transplantation using donor ECDI-SPs. In a rat-to-mouse xenogeneic islet transplant model, we show that rat ECDI-SPs …
Authors
Wang S; Tasch J; Kheradmand T; Ulaszek J; Ely S; Zhang X; Hering BJ; Miller SD; Luo X
Journal
Diabetes, Vol. 62, No. 9, pp. 3143–3150
Publisher
American Diabetes Association
Publication Date
September 1, 2013
DOI
10.2337/db12-1678
ISSN
0012-1797