Journal article
Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3
Abstract
Type 2 diabetes mellitus (T2DM) is recognized as a chronic, low-grade inflammatory disease characterized by insulin resistance and pancreatic β cell dysfunction; however, the underlying molecular mechanism remains unclear. Here, we report a key β cell-macrophage crosstalk pathway mediated by the miRNA-29-TNF-receptor-associated factor 3 (TRAF3) axis. β cell-specific transgenic miR-29a/b/c mice are predisposed to develop glucose intolerance and …
Authors
Sun Y; Zhou Y; Shi Y; Zhang Y; Liu K; Liang R; Sun P; Chang X; Tang W; Zhang Y
Journal
Cell Reports, Vol. 34, No. 1,
Publisher
Elsevier
Publication Date
1 2021
DOI
10.1016/j.celrep.2020.108576
ISSN
2639-1856
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell LineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diet, High-FatExosomesGlucoseGlucose IntoleranceHumansInflammationInsulinInsulin ResistanceInsulin-Secreting CellsMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicMicroRNAsRatsRats, WistarSignal TransductionTNF Receptor-Associated Factor 3