Journal article
Pioglitazone increases VEGFR3 expression and promotes activation of M2 macrophages via the peroxisome proliferator-activated receptor γ
Abstract
The peroxisome proliferator‑activated receptor γ (PPARγ) agonist pioglitazone has been widely used in previous studies to ameliorate diabetes mellitus and regulate inflammation. However, the present study aimed to investigate the effect of pioglitazone on macrophages and determine its impact on renal fibrosis in vivo. Firstly, bone marrow‑derived macrophages (BMDM) were used to detect the effects of pioglitazone on macrophages in vitro. It was …
Authors
Zhang C; Zhang Y; Zhang C; Liu Y; Liu Y; Xu G
Journal
Molecular Medicine Reports, Vol. 19, No. 4, pp. 2740–2748
Publisher
Spandidos Publications
Publication Date
April 2019
DOI
10.3892/mmr.2019.9945
ISSN
1791-2997