Journal article
Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB
Abstract
Saikosaponin d (SSd) is a traditional Chinese medicine that has been widely used in depression treatment. Given the lack of studies demonstrating the underlying mechanism of action of SSd in depression, the presented study was conducted with aims of investigating the effect of SSd on rats with depression-like behaviors induced by unpredicted chronic mild stress (UCMS) and its underlying molecular mechanism. To investigate the effect of SSd on …
Authors
Chao B; Huang S; Pan J; Zhang Y; Wang Y
Journal
Brain Research Bulletin, Vol. 157, , pp. 69–76
Publisher
Elsevier
Publication Date
4 2020
DOI
10.1016/j.brainresbull.2020.01.008
ISSN
0361-9230