Journal article
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1
Abstract
The association of hypercholesterolemia and obesity with airway hyperresponsiveness has drawn increasing attention to the potential role of cholesterol and lipid homeostasis in lung physiology and in chronic pulmonary diseases such as asthma. We have recently shown that activation of the nuclear hormone receptor liver X receptor (LXR) stimulates cholesterol efflux in human airway smooth muscle (hASM) cells and induces expression of the …
Authors
Delvecchio CJ; Bilan P; Nair P; Capone JP
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 295, No. 5, pp. l949–l957
Publisher
American Physiological Society
Publication Date
November 2008
DOI
10.1152/ajplung.90394.2008
ISSN
1040-0605
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ATP-Binding Cassette TransportersApolipoprotein A-IBiological TransportCholesterolCholesterol, HDLDNA-Binding ProteinsGene Expression RegulationHumansKineticsLiver X ReceptorsMuscle, SmoothOrphan Nuclear ReceptorsPhospholipidsProbucolRNA, MessengerReceptors, Cytoplasmic and NuclearRespiratory System