Journal article
Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo‐controlled clinical trial
Abstract
BACKGROUND: Several chemokines, notably eotaxin, mediate the recruitment of eosinophils into tissues via the CCR3 receptor.
OBJECTIVE: In this study, we investigated the role of CCR3 agonists in asthma by observing the effect of a small molecule antagonist of the CCR3 receptor (GW766994) on sputum eosinophil counts in patients with eosinophilic asthma.
Authors
Neighbour H; Boulet L; Lemiere C; Sehmi R; Leigh R; Sousa AR; Martin J; Dallow N; Gilbert J; Allen A
Journal
Clinical & Experimental Allergy, Vol. 44, No. 4, pp. 508–516
Publisher
Wiley
Publication Date
4 2014
DOI
10.1111/cea.12244
ISSN
0954-7894