Journal article
MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-β-Induced EMT in the Lens
Abstract
Fibrotic cataracts have been attributed to transforming growth factor-beta (TGF-β)-induced epithelial-to-mesenchymal transition (EMT). Using mouse knockout (KO) models, our laboratory has identified MMP9 as a crucial protein in the TGF-β-induced EMT process. In this study, we further revealed an absence of alpha-smooth muscle actin (αSMA) and filamentous-actin (F-actin) stress fibers in MMP9KO mouse lens epithelial cell explants (LECs). …
Authors
Liu ZZG; Taiyab A; West-Mays JA
Journal
International Journal of Molecular Sciences, Vol. 22, No. 21,
Publisher
MDPI
DOI
10.3390/ijms222111988
ISSN
1661-6596