Journal article
Persistent Left Ventricular Diastolic Stiffening Despite Cessation of Intermittent Myocardial Stretch in Swine
Abstract
Objective Building on our observation that myocardial stretch induced by an acute elevation in left ventricular (LV) preload produces reversible systolic dysfunction and cardiomyocyte apoptosis, we recently demonstrated that swine subjected to intermittent myocardial stretch (IMS) for 2 weeks exhibit an adaptive increase in LV diastolic stiffness that protects the heart from stretch‐induced injury during subsequent periods of hemodynamic …
Authors
Weil BR; Smith C; Konecny F; Techiryan G; Zimmer H; Canty JM
Journal
The FASEB Journal, Vol. 32, No. S1, pp. 848.9–848.9
Publisher
Wiley
Publication Date
April 2018
DOI
10.1096/fasebj.2018.32.1_supplement.848.9
ISSN
0892-6638