Abstract 622: Load-Independent Systolic Dysfunction and Altered Z-Disc Protein Phosphorylation in Swine with Stretch-Induced Myocardial Stunning

Objective: We recently demonstrated that a transient rise in left ventricular (LV) preload leads to a reversible reduction in LV ejection fraction in the absence of ischemia (“stretch-induced stunning”). The present study was designed to determine whether this phenomenon is characterized by impaired load independent LV systolic function and alterations in sarcomeric protein phosphorylation. Methods: Swine (n=9) received a 1 hour infusion of …