Journal article
The detection of deleterious selection using ancestors inferred from a phylogenetic history
Abstract
Summary
The widespread use of restriction endonucleases and DNA sequencing provides a wealth of data on the genetic structure of natural populations. From such data, detailed phylogenies can be constructed and qualitatively different kinds of mutational and substitutional processes can be studied. A neutral model can be constructed to describe the frequencies of sequence haplotypes according to the haplotypes from which they …
Authors
Golding GB
Journal
Genetics Research, Vol. 49, No. 1, pp. 71–82
Publisher
Hindawi
Publication Date
February 1987
DOI
10.1017/s0016672300026768
ISSN
0016-6723