Journal article
Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism
Abstract
Integrity of the cell wall is essential for bacterial survival, and as a consequence components involved in its biosynthesis can potentially be exploited as targets for antibiotics. One such potential target is CTP:glycerol-3-phosphate cytidylyltransferase. This enzyme (TarD(Sa) in Staphylococcus aureus and TagD(Bs) in Bacillus subtilis) catalyzes the formation of CDP-glycerol, which is used for the assembly of linkages between peptidoglycan …
Authors
Fong DH; Yim VC-N; D'Elia MA; Brown ED; Berghuis AM
Journal
Biochimica et Biophysica Acta, Vol. 1764, No. 1, pp. 63–69
Publisher
Elsevier
Publication Date
1 2006
DOI
10.1016/j.bbapap.2005.10.015
ISSN
0006-3002