Assembly and clustering of natural antibiotics...

Assembly and clustering of natural antibiotics guides target identification

Abstract

A retrobiosynthetic algorithm that relates known antibiotics by the similarities of their biosynthetic pathways to cluster them into distinct classes. Focusing on the telomycins helps to define the mechanism of action of this antibiotic class.

Authors

Johnston CW; Skinnider MA; Dejong CA; Rees PN; Chen GM; Walker CG; French S; Brown ED; Bérdy J; Liu DY

Journal

Nature Chemical Biology, Vol. 12, No. 4, pp. 233–239

Publisher

Springer Nature

Publication Date

April 1, 2016

DOI

10.1038/nchembio.2018

ISSN

1552-4450

Associated Experts

Eric Brown

Professor, Faculty of Health Sciences

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Nathan Magarvey

Associate Professor, Faculty of Health Sciences