Journal article
Super-activated interferon-regulatory factors can enhance plasmid immunization
Abstract
We have been investigating the adjuvant properties of two super-activated interferon-regulatory factors (IRFs), IRF-3(5D) and IRF7/3A, identified in our previous studies of structure-function relationships, for enhancing plasmid vaccines. Intramuscular injection of plasmid cocktails encoding IRF-3(5D) and IRF7/3A molecules elicited cytotoxic T cell responses in over 80% of mice following a single immunization compared to a 20% response-rate …
Authors
Bramson JL; Dayball K; Hall JR; Millar JB; Miller M; Wan YH; Lin R; Hiscott J
Journal
Vaccine, Vol. 21, No. 13-14, pp. 1363–1370
Publisher
Elsevier
Publication Date
3 2003
DOI
10.1016/s0264-410x(02)00694-1
ISSN
0264-410X