Journal article
Vesicular Stomatitis Virus as a Novel Cancer Vaccine Vector to Prime Antitumor Immunity Amenable to Rapid Boosting With Adenovirus
Abstract
Vesicular stomatitis virus (VSV) has proven to be an effective vaccine vector for immunization against viral infection, but its potential to induce an immune response to a self-tumor antigen has not been investigated. We constructed a recombinant VSV expressing human dopachrome tautomerase (hDCT) and evaluated its immunogenicity in a murine melanoma model. Intranasal delivery of VSV-hDCT activated both CD4(+) and CD8(+) DCT-specific T-cell …
Authors
Bridle BW; Boudreau JE; Lichty BD; Brunellière J; Stephenson K; Koshy S; Bramson JL; Wan Y
Journal
Molecular Therapy, Vol. 17, No. 10, pp. 1814–1821
Publisher
Elsevier
Publication Date
October 2009
DOI
10.1038/mt.2009.154
ISSN
1525-0016