Journal article
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response
Abstract
Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how representative these peripherally detected miRNA changes are to those occurring in the brain. This study aimed to use peripherally extracted neuron-derived extracellular vesicles (NDEV) to circumvent these limitations and investigate neuronal miRNA changes associated with antidepressant response. …
Authors
Saeedi S; Nagy C; Ibrahim P; Théroux J-F; Wakid M; Fiori LM; Yang J; Rotzinger S; Foster JA; Mechawar N
Journal
Molecular Psychiatry, Vol. 26, No. 12, pp. 7417–7424
Publisher
Springer Nature
Publication Date
December 2021
DOI
10.1038/s41380-021-01255-2
ISSN
1359-4184