Abnormalities in BDNF/TrkB/PI3K signaling pathways in autism (728.3)

Cortical connectivity and spine abnormalities may account for clinical features of autism. BDNF, a key spine regulator, exhibits altered isoform balance in autism. Here, we investigated whether BDNF receptors and their signaling pathways are disrupted in post‐mortem fusiform gyrus from subjects with autism compared to controls and in the valproic acid (VPA)‐induced rat model of autism. Protein levels were examined by Western blot in 11 autism …