Journal article
Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein
Abstract
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and Janssen Ad26.COV2.S COVID-19 vaccine, and it is associated with unusual thrombosis. VITT is caused by anti-platelet factor 4 (PF4) antibodies activating platelets through their FcγRIIa receptors. Antibodies that activate platelets through FcγRIIa receptors have also been identified in patients with COVID-19. …
Authors
Greinacher A; Selleng K; Mayerle J; Palankar R; Wesche J; Reiche S; Aebischer A; Warkentin TE; Muenchhoff M; Hellmuth JC
Journal
Blood, Vol. 138, No. 14, pp. 1269–1277
Publisher
American Society of Hematology
Publication Date
October 7, 2021
DOI
10.1182/blood.2021012938
ISSN
0006-4971