Journal article
Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes
Abstract
BACKGROUND: Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its association with cardiometabolic outcomes in the …
Authors
D'Mello MJJ; Ross SA; Briel M; Anand SS; Gerstein H; Paré G
Journal
Circulation Genomic and Precision Medicine, Vol. 8, No. 1, pp. 82–90
Publisher
Wolters Kluwer
Publication Date
February 2015
DOI
10.1161/circgenetics.113.000485
ISSN
1942-325X