Journal article
Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease
Abstract
INTRODUCTION: Type 2 diabetes is a strong risk factor for coronary artery disease (CAD). However, the absence of a clear reduction in CAD by intensive glucose lowering in randomized controlled trials has fuelled uncertainty regarding the causal role of dysglycaemia and CAD.
OBJECTIVE: To assess whether Mendelian randomization supports a causal role of dysglycaemia and diabetes for risk of CAD.
Authors
Ross S; Gerstein HC; Eikelboom J; Anand SS; Yusuf S; Paré G
Journal
European Heart Journal, Vol. 36, No. 23, pp. 1454–1462
Publisher
Oxford University Press (OUP)
Publication Date
June 14, 2015
DOI
10.1093/eurheartj/ehv083
ISSN
0195-668X