Journal article
Induction of interleukin‐10 and suppressor of cytokine signalling‐3 gene expression following peptide immunotherapy
Abstract
BACKGROUND: Allergen-derived (T cell epitope) peptides may be safer for immunotherapy than native allergen, as they do not cross-link immunoglobulin (Ig)E. However, HLA polymorphism results in multiple potential epitopes. Synthetic peptides of phospholipase (PL) A(2) were selected for a peptide vaccine, on the basis of binding affinity for commonly expressed HLA-DR molecules.
OBJECTIVE: To evaluate treatment with an HLA-DR-based PLA(2) peptide …
Authors
Tarzi M; Klunker S; Texier C; Verhoef A; Stapel SO; Akdis CA; Maillere B; Kay AB; Larché M
Journal
Clinical & Experimental Allergy, Vol. 36, No. 4, pp. 465–474
Publisher
Wiley
Publication Date
4 2006
DOI
10.1111/j.1365-2222.2006.02469.x
ISSN
0954-7894
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultBee VenomsCell DivisionCytokinesDrug HypersensitivityEpitopes, T-LymphocyteFemaleForkhead Transcription FactorsGene Expression RegulationHLA-DR AntigensHumansImmunoglobulin GImmunohistochemistryImmunotherapy, ActiveInjections, IntradermalInterleukin-10Interleukin-13Leukocytes, MononuclearMalePeptidesPhospholipases ASignal TransductionSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsTranscription FactorsTreatment Outcome